Genome-Wide Mapping and Interrogation of the Nmp4 Antianabolic Bone Axis

PTH is an osteoanabolic for treating osteoporosis but its potency wanes. Disabling the transcription factor nuclear matrix protein 4 (Nmp4) in healthy, ovary-intact mice enhances bone response to PTH and bone morphogenetic protein 2 and protects from unloading-induced osteopenia. These Nmp4(−/−) mic...

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Veröffentlicht in:Mol Endocrinol
Hauptverfasser: Childress, Paul, Stayrook, Keith R., Alvarez, Marta B., Wang, Zhiping, Shao, Yu, Hernandez-Buquer, Selene, Mack, Justin K., Grese, Zachary R., He, Yongzheng, Horan, Daniel, Pavalko, Fredrick M., Warden, Stuart J., Robling, Alexander G., Yang, Feng-Chun, Allen, Matthew R., Krishnan, Venkatesh, Liu, Yunlong, Bidwell, Joseph P.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Endocrine Society 2015
Schlagworte:
Original Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4552437/
https://ncbi.nlm.nih.gov/pubmed/26244796
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/me.2014-1406
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