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Epidemiological Trends Strongly Suggest Exposures as Etiologic Agents in the Pathogenesis of Sporadic Alzheimer's Disease, Diabetes Mellitus, and Non-Alcoholic Steatohepatitis

Nitrosamines mediate their mutagenic effects by causing DNA damage, oxidative stress, lipid peroxidation, and pro-inflammatory cytokine activation, which lead to increased cellular degeneration and death. However, the very same pathophysiological processes comprise the “unbuilding” blocks of aging a...

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Bibliografiset tiedot
Julkaisussa:J Alzheimers Dis
Päätekijät: de la Monte, Suzanne M., Neusner, Alexander, Chu, Jennifer, Lawton, Margot
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2009
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4551511/
https://ncbi.nlm.nih.gov/pubmed/19363256
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3233/JAD-2009-1070
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