Loss of Cdh1 and Trp53 in the uterus induces chronic inflammation with modification of tumor microenvironment

Type II endometrial carcinomas are estrogen independent, poorly differentiated tumors that behave in an aggressive manner. Since TP53 mutation and CDH1 inactivation occur in 80% of human endometrial type II carcinomas, we hypothesized that mouse uteri lacking both Trp53 and Cdh1 would exhibit a phen...

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Bibliographic Details
Published in:Oncogene
Main Authors: Stodden, Genna R., Lindberg, Mallory E., King, Mandy L., Paquet, Marilène, MacLean, James A., Mann, Jordan L., DeMayo, Francesco J., Lydon, John P., Hayashi, Kanako
Format: Artigo
Language:Inglês
Published: 2014
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4551401/
https://ncbi.nlm.nih.gov/pubmed/24998851
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2014.193
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