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Single cell tuning of Myc expression by antigen receptor signal strength and interleukin-2 in T lymphocytes
Myc controls the metabolic reprogramming that supports effector T cell differentiation. The expression of Myc is regulated by the T cell antigen receptor (TCR) and pro-inflammatory cytokines such as interleukin-2 (IL-2). We now show that the TCR is a digital switch for Myc mRNA and protein expressio...
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Gepubliceerd in: | EMBO J |
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Hoofdauteurs: | , , , , , , , , |
Formaat: | Artigo |
Taal: | Inglês |
Gepubliceerd in: |
John Wiley & Sons, Ltd
2015
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Onderwerpen: | |
Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4551349/ https://ncbi.nlm.nih.gov/pubmed/26136212 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201490252 |
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