Single cell tuning of Myc expression by antigen receptor signal strength and interleukin-2 in T lymphocytes

Myc controls the metabolic reprogramming that supports effector T cell differentiation. The expression of Myc is regulated by the T cell antigen receptor (TCR) and pro-inflammatory cytokines such as interleukin-2 (IL-2). We now show that the TCR is a digital switch for Myc mRNA and protein expressio...

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Foilsithe in:EMBO J
Main Authors: Preston, Gavin C, Sinclair, Linda V, Kaskar, Aneesa, Hukelmann, Jens L, Navarro, Maria N, Ferrero, Isabel, MacDonald, H Robson, Cowling, Victoria H, Cantrell, Doreen A
Formáid: Artigo
Teanga:Inglês
Foilsithe: John Wiley & Sons, Ltd 2015
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Articles
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4551349/
https://ncbi.nlm.nih.gov/pubmed/26136212
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201490252
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