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REMARKABLE SELECTIVE CONSTRAINTS ON EXONIC DINUCLEOTIDE REPEATS
Long dinucleotide repeats found in exons present a substantial mutational hazard: mutations at these loci occur often and generate frame shifts. Here, we provide clear and compelling evidence that exonic dinucleotides experience strong selective constraint. In humans, only 18 exonic dinucleotides ha...
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| Udgivet i: | Evolution |
|---|---|
| Main Authors: | , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2014
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4550590/ https://ncbi.nlm.nih.gov/pubmed/24899386 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/evo.12460 |
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