Phosphorylation negatively regulates the function of coactivator PC4.

Human positive cofactor 4 (PC4) mediates activator-dependent transcription by RNA polymerase II, apparently through interactions with transcriptional activators and the basal transcription machinery. We report here that PC4 function is modulated by in vivo phosphorylation. Protein-protein interactio...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Ge, H, Zhao, Y, Chait, B T, Roeder, R G
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1994
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC45505/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7809103/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.91.26.12691
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