Tetrahydrohyperforin Inhibits the Proteolytic Processing of Amyloid Precursor Protein and Enhances Its Degradation by Atg5-Dependent Autophagy

Alzheimer's disease (AD) is a neurodegenerative disorder characterized by the accumulation of amyloid-β (Aβ) peptide. We have previously shown that the compound tetrahydrohyperforin (IDN5706) prevents accumulation of Aβ species in an in vivo model of AD, however the mechanism that explains this...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Cavieres, Viviana A., González, Alexis, Muñoz, Vanessa C., Yefi, Claudia P., Bustamante, Hianara A., Barraza, Rafael R., Tapia-Rojas, Cheril, Otth, Carola, Barrera, María José, González, Carlos, Mardones, Gonzalo A., Inestrosa, Nibaldo C., Burgos, Patricia V.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4550396/
https://ncbi.nlm.nih.gov/pubmed/26308941
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0136313
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