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Pluripotency, Differentiation, and Reprogramming: A Gene Expression Dynamics Model with Epigenetic Feedback Regulation

Embryonic stem cells exhibit pluripotency: they can differentiate into all types of somatic cells. Pluripotent genes such as Oct4 and Nanog are activated in the pluripotent state, and their expression decreases during cell differentiation. Inversely, expression of differentiation genes such as Gata6...

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Detalhes bibliográficos
Publicado no:PLoS Comput Biol
Main Authors: Miyamoto, Tadashi, Furusawa, Chikara, Kaneko, Kunihiko
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4550282/
https://ncbi.nlm.nih.gov/pubmed/26308610
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1004476
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