Evaluation of spiropiperidine hydantoins as a novel class of antimalarial agents

Given the rise of parasite resistance to all currently used antimalarial drugs, the identification of novel chemotypes with unique mechanisms of action is of paramount importance. Since Plasmodium expresses a number of aspartic proteases necessary for its survival, we have mined antimalarial dataset...

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Publicado no:Bioorg Med Chem
Main Authors: Meyers, Marvin J., Anderson, Elizabeth J., McNitt, Sarah A., Krenning, Thomas M., Singh, Megh, Xu, Jing, Zeng, Wentian, Qin, Limei, Xu, Wanwan, Zhao, Siting, Qin, Li, Eickhoff, Christopher S., Oliva, Jonathan, Campbell, Mary A., Arnett, Stacy D., Prinsen, Michael J., Griggs, David W., Ruminski, Peter G., Goldberg, Daniel E., Ding, Ke, Liu, Xiaorong, Tu, Zhengchao, Tortorella, Micky D., Sverdrup, Francis M., Chen, Xiaoping
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4550221/
https://ncbi.nlm.nih.gov/pubmed/25797165
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2015.02.050
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