Metabolic engineering of Bacillus subtilis for redistributing the carbon flux to 2,3-butanediol by manipulating NADH levels

BACKGROUND: Acetoin reductase (Acr) catalyzes the conversion of acetoin to 2,3-butanediol (2,3-BD) with concomitant oxidation of NADH to NAD(+). Therefore, intracellular 2,3-BD production is likely governed by the quantities of rate-limiting factor(s) Acr and/or NADH. Previously, we showed that a hi...

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Vydáno v:Biotechnol Biofuels
Hlavní autoři: Yang, Taowei, Rao, Zhiming, Hu, Guiyuan, Zhang, Xian, Liu, Mei, Dai, Yue, Xu, Meijuan, Xu, Zhenghong, Yang, Shang-Tian
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2015
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4549875/
https://ncbi.nlm.nih.gov/pubmed/26312069
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13068-015-0320-1
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