Increased expression of the interleukin-1 receptor-associated kinase (IRAK)-1 is associated with adipose tissue inflammatory state in obesity

BACKGROUND: The emerging role of TLR2/4 as immuno-metabolic receptors points to key involvement of TLR/IL-1R/MyD88 pathway in obesity/type-2 diabetes (T2D). IL1R-associated kinase (IRAK)-1 is a critical adapter protein (serine/threonine kinase) of this signaling pathway. The changes in adipose tissu...

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Veröffentlicht in:Diabetol Metab Syndr
Hauptverfasser: Ahmad, Rasheed, Shihab, Puthiyaveetil Kochumon, Thomas, Reeby, Alghanim, Munera, Hasan, Amal, Sindhu, Sardar, Behbehani, Kazem
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2015
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Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4549832/
https://ncbi.nlm.nih.gov/pubmed/26312071
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13098-015-0067-7
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