Systems Genetics Reveals the Functional Context of PCOS Loci and Identifies Genetic and Molecular Mechanisms of Disease Heterogeneity

Genome wide association studies (GWAS) have revealed 11 independent risk loci for polycystic ovary syndrome (PCOS), a common disorder in young women characterized by androgen excess and oligomenorrhea. To put these risk loci and the single nucleotide polymorphisms (SNPs) therein into functional cont...

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Bibliografske podrobnosti
izdano v:PLoS Genet
Main Authors: Jones, Michelle R., Brower, Meredith A., Xu, Ning, Cui, Jinrui, Mengesha, Emebet, Chen, Yii-Der I., Taylor, Kent D., Azziz, Ricardo, Goodarzi, Mark O.
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2015
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4549292/
https://ncbi.nlm.nih.gov/pubmed/26305227
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1005455
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