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Selective repression of RET proto-oncogene in medullary thyroid carcinoma by a natural alkaloid berberine

BACKGROUND: The gain-of-function mutation of the RET proto-oncogene, which encodes a receptor tyrosine kinase, is strongly associated with the development of several medullary thyroid carcinomas (MTCs). Thus, the RET protein has been explored as an excellent target for progressive and advanced MTC....

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Sonraí Bibleagrafaíochta
Foilsithe in:BMC Cancer
Main Authors: Kumarasamy, Vishnu Muthuraj, Shin, Yoon-Joo, White, John, Sun, Daekyu
Formáid: Artigo
Teanga:Inglês
Foilsithe: BioMed Central 2015
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4549123/
https://ncbi.nlm.nih.gov/pubmed/26307103
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-015-1610-5
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