Targeting procaspase-3 with WF-208, a novel PAC-1 derivative, causes selective cancer cell apoptosis

Caspase-3 is a critical effector caspase in apoptosis cascade, and is often over-expressed in many cancer tissues. The first synthesized procaspase-3 activator, PAC-1, induces cancer cell apoptosis and exhibits antitumour activity in murine xenograft models. To identify more potent procaspase-3 acti...

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Detalhes bibliográficos
Publicado no:J Cell Mol Med
Main Authors: Wang, Fangyang, Liu, Yajing, Wang, Lihui, Yang, Jingyu, Zhao, Yanfang, Wang, Nannan, Cao, Qi, Gong, Ping, Wu, Chunfu
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley & Sons, Ltd 2015
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4549042/
https://ncbi.nlm.nih.gov/pubmed/25754465
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jcmm.12566
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