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Coevolutionary analyses require phylogenetically deep alignments and better null models to accurately detect inter-protein contacts within and between species
BACKGROUND: When biomolecules physically interact, natural selection operates on them jointly. Contacting positions in protein and RNA structures exhibit correlated patterns of sequence evolution due to constraints imposed by the interaction, and molecular arms races can develop between interacting...
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| Veröffentlicht in: | BMC Bioinformatics |
|---|---|
| Hauptverfasser: | , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
BioMed Central
2015
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4549020/ https://ncbi.nlm.nih.gov/pubmed/26303588 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12859-015-0677-y |
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