Comedications alter drug-induced liver injury reporting frequency: Data mining in the WHO VigiBase™

Polypharmacy is common, and may modify mechanisms of drug-induced liver injury. We examined the effect of these drug–drug interactions on liver safety reports of four drugs highly associated with hepatotoxicity. In the WHO VigiBase™, liver event reports were examined for acetaminophen, isoniazid, va...

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Detalhes bibliográficos
Publicado no:Regul Toxicol Pharmacol
Main Authors: Suzuki, Ayako, Yuen, Nancy A., Ilic, Katarina, Miller, Richard T., Reese, Melinda J., Brown, H. Roger, Ambroso, Jeffrey I., Falls, J. Gregory, Hunt, Christine M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4548888/
https://ncbi.nlm.nih.gov/pubmed/25988394
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yrtph.2015.05.004
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