NKX2-5 mutations causative for congenital heart disease retain functionality and are directed to hundreds of targets

We take a functional genomics approach to congenital heart disease mechanism. We used DamID to establish a robust set of target genes for NKX2-5 wild type and disease associated NKX2-5 mutations to model loss-of-function in gene regulatory networks. NKX2-5 mutants, including those with a crippled ho...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Bouveret, Romaric, Waardenberg, Ashley J, Schonrock, Nicole, Ramialison, Mirana, Doan, Tram, de Jong, Danielle, Bondue, Antoine, Kaur, Gurpreet, Mohamed, Stephanie, Fonoudi, Hananeh, Chen, Chiann-mun, Wouters, Merridee A, Bhattacharya, Shoumo, Plachta, Nicolas, Dunwoodie, Sally L, Chapman, Gavin, Blanpain, Cédric, Harvey, Richard P
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2015
Assuntos:
Developmental Biology and Stem Cells
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4548209/
https://ncbi.nlm.nih.gov/pubmed/26146939
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.06942
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