RAPT1, a mammalian homolog of yeast Tor, interacts with the FKBP12/rapamycin complex.
Rapamycin is a potent immunosuppressant that blocks the G1/S transition in antigen-activated T cells and in yeast. The similar effects of rapamycin in animal cells and yeast suggest that the biochemical steps affected by rapamycin are conserved. Using a two-hybrid system we isolated mammalian clones...
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| Publicado en: | Proc Natl Acad Sci U S A |
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| Autores principales: | , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
National Academy of Sciences
1994
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC45481/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7809080/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.91.26.12574 |
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