Phospholipase D2 drives mortality in sepsis by inhibiting neutrophil extracellular trap formation and down-regulating CXCR2

We determined the function of phospholipase D2 (PLD2) in host defense in highly lethal mouse models of sepsis using PLD2(−/−) mice and a PLD2-specific inhibitor. PLD2 deficiency not only increases survival but also decreases vital organ damage during experimental sepsis. Production of several inflam...

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Dades bibliogràfiques
Publicat a:J Exp Med
Autors principals: Lee, Sung Kyun, Kim, Sang Doo, Kook, Minsoo, Lee, Ha Young, Ghim, Jaewang, Choi, Youngwoo, Zabel, Brian A., Ryu, Sung Ho, Bae, Yoe-Sik
Format: Artigo
Idioma:Inglês
Publicat: The Rockefeller University Press 2015
Matèries:
Brief Definitive Report
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4548059/
https://ncbi.nlm.nih.gov/pubmed/26282875
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20141813
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