Protein-Derived Acetaminophen-Cysteine Can Be Detected After Repeated Supratherapeutic Ingestion of Acetaminophen in the Absence of Hepatotoxicity

Generation of protein-derived acetaminophen-cysteine (APAP-CYS) is reported after ingestion of large and therapeutic dosages of acetaminophen in healthy and in liver-damaged patients. The incidence of protein-derived APAP-CYS adducts in repeated supratherapeutic dosages of APAP is not known. Methods...

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Библиографические подробности
Опубликовано в: :J Med Toxicol
Главные авторы: O’Malley, GF, Mizrahi, F, Giraldo, P, O’Malley, RN, Rollins, D, Wilkins, D
Формат: Artigo
Язык:Inglês
Опубликовано: Springer US 2015
Предметы:
Toxicology Investigation
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4547951/
https://ncbi.nlm.nih.gov/pubmed/26002216
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s13181-015-0484-x
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