Carbenoxolone induces permeability transition pore opening in rat mitochondria via the translocator protein TSPO and connexin43

Ca(2+)-induced permeability transition pore (mPTP) opening in isolated rat brain mitochondria is promoted through targeting of connexin43. After a threshold Ca(2+) load, mitochondrial membrane potential drops and efflux of accumulated Ca(2+) from the mitochondrial matrix occurs, indicating the mPTP...

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Publicat a:Arch Biochem Biophys
Autors principals: Azarashvili, Tamara, Baburina, Yulia, Grachev, Dmitry, Krestinina, Olga, Papadopoulos, Vassilios, Lemasters, John J., Odinokova, Irina, Reiser, Georg
Format: Artigo
Idioma:Inglês
Publicat: 2014
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4547858/
https://ncbi.nlm.nih.gov/pubmed/24995971
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.abb.2014.06.027
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