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Thermodynamics of Micelle Formation and Membrane Fusion Modulate Antimicrobial Lipopeptide Activity

Antimicrobial lipopeptides (AMLPs) are antimicrobial drug candidates that preferentially target microbial membranes. One class of AMLPs, composed of cationic tetrapeptides attached to an acyl chain, have minimal inhibitory concentrations in the micromolar range against a range of bacteria and fungi....

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Bibliographic Details
Published in:Biophys J
Main Authors: Lin, Dejun, Grossfield, Alan
Format: Artigo
Language:Inglês
Published: The Biophysical Society 2015
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4547331/
https://ncbi.nlm.nih.gov/pubmed/26287627
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2015.07.011
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