Identification of a functional hotspot on ubiquitin required for stimulation of methyltransferase activity on chromatin

Ubiquitylation of histone H2B at lysine 120 (H2B-Ub) plays a critical role in transcriptional elongation, chromatin conformation, as well as the regulation of specific histone H3 methylations. Herein, we report a strategy for the site-specific chemical attachment of ubiquitin to preassembled nucleos...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Holt, Matthew T., David, Yael, Pollock, Sam, Tang, Zhanyun, Jeon, Jongcheol, Kim, Jaehoon, Roeder, Robert G., Muir, Tom W.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2015
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4547310/
https://ncbi.nlm.nih.gov/pubmed/26240340
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1504483112
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