Mitochondrial ATP synthase is dispensable in blood-stage Plasmodium berghei rodent malaria but essential in the mosquito phase

Mitochondrial ATP synthase is driven by chemiosmotic oxidation of pyruvate derived from glycolysis. Blood-stage malaria parasites eschew chemiosmosis, instead relying almost solely on glycolysis for their ATP generation, which begs the question of whether mitochondrial ATP synthase is necessary duri...

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Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Sturm, Angelika, Mollard, Vanessa, Cozijnsen, Anton, Goodman, Christopher D., McFadden, Geoffrey I.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2015
Soggetti:
Symbioses Becoming Permanent: The Origins and Evolutionary Trajectories of Organelles Sackler Colloquium
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4547259/
https://ncbi.nlm.nih.gov/pubmed/25831536
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1423959112
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