Mechanisms linked to differences in the mutagenic potential of 1,3-dinitropyrene and 1,8-dinitropyrene

This study explores and characterizes the toxicity of two closely related carcinogenic dinitro-pyrenes (DNPs), 1,3-DNP and 1,8-DNP, in human bronchial epithelial BEAS-2B cells and mouse hepatoma Hepa1c1c7 cells. Neither 1,3-DNP nor 1,8-DNP (3–30 μM) induced cell death in BEAS-2B cells. In Hepa1c1c7...

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Detalles Bibliográficos
Publicado en:Toxicol Rep
Autores principales: Holme, J.A., Nyvold, H.E., Tat, V., Arlt, V.M., Bhargava, A., Gutzkow, K.B., Solhaug, A., Låg, M., Becher, R., Schwarze, P.E., Ask, K., Ekeren, L., Øvrevik, J.
Formato: Artigo
Lenguaje:Inglês
Publicado: Elsevier 2014
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4547165/
https://ncbi.nlm.nih.gov/pubmed/28962260
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.toxrep.2014.07.009
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