Prion Protein—Antibody Complexes Characterized by Chromatography-Coupled Small-Angle X-Ray Scattering

Aberrant self-assembly, induced by structural misfolding of the prion proteins, leads to a number of neurodegenerative disorders. In particular, misfolding of the mostly α-helical cellular prion protein (PrP(C)) into a β-sheet-rich disease-causing isoform (PrP(Sc)) is the key molecular event in the...

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Salvato in:
Dettagli Bibliografici
Pubblicato in:Biophys J
Autori principali: Carter, Lester, Kim, Seung Joong, Schneidman-Duhovny, Dina, Stöhr, Jan, Poncet-Montange, Guillaume, Weiss, Thomas M., Tsuruta, Hiro, Prusiner, Stanley B., Sali, Andrej
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Biophysical Society 2015
Soggetti:
Proteins and Nucleic Acids
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4547163/
https://ncbi.nlm.nih.gov/pubmed/26287631
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2015.06.065
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