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Prefrontal dopamine regulates fear reinstatement through the downregulation of extinction circuits
Prevention of relapses is a major challenge in treating anxiety disorders. Fear reinstatement can cause relapse in spite of successful fear reduction through extinction-based exposure therapy. By utilising a contextual fear-conditioning task in mice, we found that reinstatement was accompanied by de...
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| Izdano u: | eLife |
|---|---|
| Glavni autori: | , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
eLife Sciences Publications, Ltd
2015
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4547090/ https://ncbi.nlm.nih.gov/pubmed/26226637 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.08274 |
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