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Extent of systemic spread determines CD8(+) T cell immunodominance for laboratory strains, smallpox vaccines and zoonotic isolates of vaccinia virus()

CD8(+) T cells that recognize virus-derived peptides presented on MHC class I (pMHC) are vital anti-viral effectors. The pMHC presented by any given virus vary greatly in immunogenicity allowing them to be ranked in an immunodominance hierarchy. However, the full range of parameters that determine i...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Immunol
Prif Awduron: Flesch, Inge E.A., Hollett, Natasha A., Wong, Yik Chun, Quinan, Bárbara Resende, Howard, Debbie, da Fonseca, Flávio G., Tscharke, David C.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2015
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4546862/
https://ncbi.nlm.nih.gov/pubmed/26195812
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1402508
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