Tumor promotion by γ and suppression by β non-muscle actin isoforms

Here we have shown that β-cytoplasmic actin acts as a tumor suppressor, inhibiting cell growth and invasion in vitro and tumor growth in vivo. In contrast, γ-cytoplasmic actin increases the oncogenic potential via ERK1/2, p34-Arc, WAVE2, cofilin1, PP1 and other regulatory proteins. There is a positi...

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Bibliographic Details
Published in:Oncotarget
Main Authors: Dugina, Vera, Khromova, Natalya, Rybko, Vera, Blizniukov, Oleg, Shagieva, Galina, Chaponnier, Christine, Kopnin, Boris, Kopnin, Pavel
Format: Artigo
Language:Inglês
Published: Impact Journals LLC 2015
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Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4546487/
https://ncbi.nlm.nih.gov/pubmed/26008973
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