MicroRNA-33a-mediated downregulation of Pim-3 kinase expression renders human pancreatic cancer cells sensitivity to gemcitabine

Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal cancers, with less than 5% of patients surviving 5 years beyond diagnosis. Systemic therapies, particularly gemcitabine, have a modest clinical benefit, but chemoresistance limits their efficacy. Here, we demonstrate that plasma miR-3...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Liang, Chen, Yu, Xian-Jun, Guo, Xiao-Zhong, Sun, Meng-Hong, Wang, Zhen, Song, Yao, Ni, Quan-Xing, Li, Hong-Yu, Mukaida, Naofumi, Li, Ying-Yi
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2015
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4546478/
https://ncbi.nlm.nih.gov/pubmed/25971209
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