Doxycycline down-regulates DNA-PK and radiosensitizes tumor initiating cells: Implications for more effective radiation therapy

DNA-PK is an enzyme that is required for proper DNA-repair and is thought to confer radio-resistance in cancer cells. As a consequence, it is a high-profile validated target for new pharmaceutical development. However, no FDA-approved DNA-PK inhibitors have emerged, despite many years of drug discov...

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Опубликовано в: :Oncotarget
Главные авторы: Lamb, Rebecca, Fiorillo, Marco, Chadwick, Amy, Ozsvari, Bela, Reeves, Kimberly J., Smith, Duncan L., Clarke, Robert B., Howell, Sacha J., Cappello, Anna Rita, Martinez-Outschoorn, Ubaldo E., Peiris-Pagès, Maria, Sotgia, Federica, Lisanti, Michael P.
Формат: Artigo
Язык:Inglês
Опубликовано: Impact Journals LLC 2015
Предметы:
Priority Research Paper
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4546447/
https://ncbi.nlm.nih.gov/pubmed/26087309
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