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Reliable scaling of position weight matrices for binding strength comparisons between transcription factors

BACKGROUND: Scoring DNA sequences against Position Weight Matrices (PWMs) is a widely adopted method to identify putative transcription factor binding sites. While common bioinformatics tools produce scores that can reflect the binding strength between a specific transcription factor and the DNA, th...

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Detalles Bibliográficos
Publicado en:BMC Bioinformatics
Autores principales: Ma, Xiaoyan, Ezer, Daphne, Navarro, Carmen, Adryan, Boris
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2015
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4545934/
https://ncbi.nlm.nih.gov/pubmed/26289072
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12859-015-0666-1
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