Bortezomib and Fenretinide Induce Synergistic Cytotoxicity in Mantle Cell Lymphoma Via Apoptosis, Cell Cycle Dysregulation, and IκBα Kinase Down-regulation

BACKGROUND: Mantle cell lymphoma (MCL) remains incurable for most patients and proteasome inhibitors like bortezomib induce responses in a minority of patients with relapsed disease. Fenretinide is a retinoid that has shown preclinical activity in B-cell lymphomas. We hypothesized that these agents...

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Udgivet i:Anticancer Drugs
Main Authors: Cowan, Andrew J., Frayo, Shani L., Press, Oliver W., Palanca-Wessels, Maria C., Pagel, John M., Green, Damian J., Gopal, Ajay K.
Format: Artigo
Sprog:Inglês
Udgivet: 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4545689/
https://ncbi.nlm.nih.gov/pubmed/26237500
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/CAD.0000000000000274
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