Exploring naphthyl-carbohydrazides as inhibitors of influenza A viruses

A library of hydrazide derivatives was synthesized to target non-structural protein 1 of influenza A virus (NS1) as a means to develop anti-influenza drug leads. The lead compound 3-hydroxy-N-[(Z)-1-(5,6,7,8-tetrahydronaphthalen-2-yl)ethylideneamino]naphthalene-2-carboxamide, which we denoted as “HE...

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Detalhes bibliográficos
Publicado no:Eur J Med Chem
Main Authors: Barman, Sanmitra, You, Lei, Chen, Ran, Codrea, Vlad, Kago, Grace, Edupuganti, Ramakrishna, Robertus, Jon, Krug, Robert M., Anslyn, Eric V.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4545637/
https://ncbi.nlm.nih.gov/pubmed/24287556
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2013.10.063
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