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Optimization of Synthetic Proteins: Identification of Interpositional Dependencies Indicating Structurally and/or Functionally Linked Residues
Protein alignments are commonly used to evaluate the similarity of protein residues, and the derived consensus sequence used for identifying functional units (e.g., domains). Traditional consensus-building models fail to account for interpositional dependencies – functionally required covariation of...
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| Published in: | J Vis Exp |
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| Main Authors: | , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
MyJove Corporation
2015
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4545158/ https://ncbi.nlm.nih.gov/pubmed/26274377 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3791/52878 |
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