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Beyond CTLA-4 and PD-1, the Generation Z of Negative Checkpoint Regulators
In the last two years, clinical trials with blocking antibodies to the negative checkpoint regulators CTLA-4 and PD-1 have rekindled the hope for cancer immunotherapy. Multiple negative checkpoint regulators protect the host against autoimmune reactions but also restrict the ability of T cells to ef...
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| Publicado en: | Front Immunol |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Frontiers Media S.A.
2015
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4544156/ https://ncbi.nlm.nih.gov/pubmed/26347741 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2015.00418 |
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