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Yeast telomerase RNA: A flexible scaffold for protein subunits

In the yeast Saccharomyces cerevisiae, distinct regions of the 1.2-kb telomerase RNA (TLC1) bind to the catalytic subunit Est2p and to accessory proteins. In particular, a bulged stem structure binds the essential regulatory subunit Est1p. We now show that the Est1p-binding domain of the RNA can be...

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Autors principals: Zappulla, David C., Cech, Thomas R.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2004
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC454382/
https://ncbi.nlm.nih.gov/pubmed/15226497
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0403641101
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