The Orphan Nuclear Receptor NR4A1 Protects Pancreatic β-Cells from Endoplasmic Reticulum (ER) Stress-mediated Apoptosis

The role of NR4A1 in apoptosis is controversial. Pancreatic β-cells often face endoplasmic reticulum (ER) stress under adverse conditions such as high free fatty acid (FFA) concentrations and sustained hyperglycemia. Severe ER stress results in β-cell apoptosis. The aim of this study was to analyze...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Yu, Cong, Cui, Shang, Zong, Chen, Gao, Weina, Xu, Tongfu, Gao, Peng, Chen, Jicui, Qin, Dandan, Guan, Qingbo, Liu, Yuantao, Fu, Yuchang, Li, Xia, Wang, Xiangdong
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2015
Assuntos:
Molecular Bases of Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4543630/
https://ncbi.nlm.nih.gov/pubmed/26157144
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.654863
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