Reciprocal Regulation of Substance P and IL-12/IL-23 and the Associated Cytokines, IFNγ/IL-17: A Perspective on the Relevance of This Interaction to Multiple Sclerosis

The neuropeptide substance P (SP) exhibits cytokine-like properties and exerts different effects in autoimmune inflammation. Various immune cells express SP and its neurokinin-1 receptor (NK1R) isoforms. A role for SP has been demonstrated in a number of autoimmune conditions, including multiple scl...

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Bibliographic Details
Published in:J Neuroimmune Pharmacol
Main Authors: Vilisaar, Janek, Kawabe, Kiyokazu, Braitch, Manjit, Aram, Jehan, Furtun, Yasemin, Fahey, Angela J., Chopra, Mark, Tanasescu, Radu, Tighe, Patrick J., Gran, Bruno, Pothoulakis, Charalabos, Constantinescu, Cris S.
Format: Artigo
Language:Inglês
Published: Springer US 2015
Subjects:
Perspective
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4543419/
https://ncbi.nlm.nih.gov/pubmed/25690155
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11481-015-9589-x
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