A Mechanistic Investigation of the Enhanced Cleavage at Histidine in the Gas-Phase Dissociation of Protonated Peptides

Enhanced gas-phase cleavage of peptides adjacent to histidine was investigated. The peptides examined were angiotensins III (RVYIHPF) and IV (VYIHPF) as well as synthetic peptide analogs with altered key residues ((R)VYI-X-Z-F; X=F or H and Z=A, P or Sar) or a fixed charge Φ(3)P(+)CH(2)C(O)-VYIHPF....

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Bibliographic Details
Published in:Anal Chem
Main Authors: Tsaprailis, George, Nair, Hari, Zhong, Wenqing, Kuppannan, Krishnamoorthy, Futrell, Jean H., Wysocki, Vicki H.
Format: Artigo
Language:Inglês
Published: 2004
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4543267/
https://ncbi.nlm.nih.gov/pubmed/15053674
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ac034971j
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