Herpes Simplex Encephalitis: Lack of Clinical Benefit of Long-term Valacyclovir Therapy

Background. Despite the proven efficacy of acyclovir (ACV) therapy, herpes simplex encephalitis (HSE) continues to cause substantial morbidity and mortality. Among patients with HSE treated with ACV, the mortality rate is approximately 14%–19%. Among survivors, 45%–60% have neuropsychological sequel...

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Detalhes bibliográficos
Publicado no:Clin Infect Dis
Main Authors: Gnann, John W., Sköldenberg, Birgit, Hart, John, Aurelius, Elisabeth, Schliamser, Silvia, Studahl, Marie, Eriksson, Britt-Marie, Hanley, Daniel, Aoki, Fred, Jackson, Alan C., Griffiths, Paul, Miedzinski, Lil, Hanfelt-Goade, Diane, Hinthorn, Daniel, Ahlm, Clas, Aksamit, Allen, Cruz-Flores, Salvador, Dale, Ilet, Cloud, Gretchen, Jester, Penelope, Whitley, Richard J.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2015
Assuntos:
Articles and Commentaries
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4542890/
https://ncbi.nlm.nih.gov/pubmed/25956891
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/cid/civ369
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