Blockade of the acute activation of mTOR complex 1 decreases hypertrophy development in rats with severe aortic valve regurgitation

BACKGROUND: Hypertrophy (H) is an adaptive response of the heart to a hemodynamic overload. Severe left ventricular (LV) volume overload (VO) from valve regurgitations (aortic (AR) or mitral regurgitation) leads to eccentric LVH. Increased protein turnover is a major event during development of LVH...

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Detalhes bibliográficos
Publicado no:Springerplus
Main Authors: Drolet, Marie-Claude, Desbiens-Brassard, Vincent, Roussel, Elise, Tu, Veronique, Couet, Jacques, Arsenault, Marie
Formato: Artigo
Idioma:Inglês
Publicado em: Springer International Publishing 2015
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4542859/
https://ncbi.nlm.nih.gov/pubmed/26306297
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40064-015-1230-1
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