Reconstruction of clonal trees and tumor composition from multi-sample sequencing data

Motivation: DNA sequencing of multiple samples from the same tumor provides data to analyze the process of clonal evolution in the population of cells that give rise to a tumor. Results: We formalize the problem of reconstructing the clonal evolution of a tumor using single-nucleotide mutations as t...

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Udgivet i:Bioinformatics
Main Authors: El-Kebir, Mohammed, Oesper, Layla, Acheson-Field, Hannah, Raphael, Benjamin J.
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2015
Fag:
Ismb/Eccb 2015 Proceedings Papers Committee July 10 to July 14, 2015, Dublin, Ireland
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4542783/
https://ncbi.nlm.nih.gov/pubmed/26072510
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/bioinformatics/btv261
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