Synthesis and biological activities of highly potent antagonists of growth hormone-releasing hormone.

In the search for antagonists of human growth hormone-releasing hormone (hGHRH) with high activity, 22 analogs were synthesized by solid-phase methods, purified, and tested biologically. Within the N-terminal sequence of 28 or 29 amino acids of hGHRH, all the analogs contained D-Arg2, Phe(4-Cl)6 (pa...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Zarandi, M, Horvath, J E, Halmos, G, Pinski, J, Nagy, A, Groot, K, Rekasi, Z, Schally, A V
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1994
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC45424/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7991622/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.91.25.12298
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