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New Insight into Filamentous Hemagglutinin Secretion Reveals a Role for Full-Length FhaB in Bordetella Virulence

Bordetella filamentous hemagglutinin (FHA), a primary component of acellular pertussis vaccines, contributes to virulence, but how it functions mechanistically is unclear. FHA is first synthesized as an ~370-kDa preproprotein called FhaB. Removal of an N-terminal signal peptide and a large C-termina...

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Publicado en:mBio
Main Authors: Melvin, Jeffrey A., Scheller, Erich V., Noël, Christopher R., Cotter, Peggy A.
Formato: Artigo
Idioma:Inglês
Publicado: American Society of Microbiology 2015
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4542190/
https://ncbi.nlm.nih.gov/pubmed/26286694
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.01189-15
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