Human DNA polymerase alpha gene expression is cell proliferation dependent and its primary structure is similar to both prokaryotic and eukaryotic replicative DNA polymerases.

We have isolated cDNA clones encoding the human DNA polymerase alpha catalytic polypeptide. Studies of the human DNA polymerase alpha steady-state mRNA levels in quiescent cells stimulated to proliferate, or normal cells compared to transformed cells, demonstrate that the polymerase alpha mRNA, like...

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Bibliographic Details
Main Authors: Wong, S W, Wahl, A F, Yuan, P M, Arai, N, Pearson, B E, Arai, K, Korn, D, Hunkapiller, M W, Wang, T S
Format: Artigo
Language:Inglês
Published: 1988
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC454213/
https://ncbi.nlm.nih.gov/pubmed/3359994
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