Increased nuclear suppressor of cytokine signaling 1 in asthmatic bronchial epithelium suppresses rhinovirus induction of innate interferons

BACKGROUND: Rhinovirus infections are the dominant cause of asthma exacerbations, and deficient virus induction of IFN-α/β/λ in asthmatic patients is important in asthma exacerbation pathogenesis. Mechanisms causing this interferon deficiency in asthmatic patients are unknown. OBJECTIVE: We sought t...

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Veröffentlicht in:J Allergy Clin Immunol
Hauptverfasser: Gielen, Vera, Sykes, Annemarie, Zhu, Jie, Chan, Brian, Macintyre, Jonathan, Regamey, Nicolas, Kieninger, Elisabeth, Gupta, Atul, Shoemark, Amelia, Bossley, Cara, Davies, Jane, Saglani, Sejal, Walker, Patrick, Nicholson, Sandra E., Dalpke, Alexander H., Kon, Onn-Min, Bush, Andrew, Johnston, Sebastian L., Edwards, Michael R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Mosby 2015
Schlagworte:
Mechanisms of Allergy and Clinical Immunology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4541718/
https://ncbi.nlm.nih.gov/pubmed/25630941
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaci.2014.11.039
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