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A Phase I Clinical Trial of Tiopronin, a Putative Neuroprotective Agent, in Aneurysmal Subarachnoid Hemorrhage
BACKGROUND: The neurotoxic aldehyde 3-aminopropanal (3-AP) contributes to brain injury following cerebral ischemia. Tiopronin (N-2-mercaptopropionyl-glycine[N-2-MPG]) is a US Food and Drug Administration (FDA)-approved drug for the treatment of cystinuria and a putative neuroprotective agent that ha...
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| Publicado no: | Neurosurgery |
|---|---|
| Main Authors: | , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4540229/ https://ncbi.nlm.nih.gov/pubmed/20559104 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1227/01.NEU.0000370919.93259.3C |
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