Selection and Counterselection of Hia Expression Reveals a Key Role for Phase-Variable Expression of Hia in Infection Caused by Nontypeable Haemophilus influenzae

Hia is a major adhesin of nontypeable Haemophilus influenzae (NTHi) and has long been investigated as a vaccine candidate. Here we show that Hia phase variation is controlled by changes in the length of a polythymidine tract located in the hia promoter. Studies of an invasive clinical isolate (strai...

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Udgivet i:J Infect Dis
Main Authors: Atack, John M., Winter, Linda E., Jurcisek, Joseph A., Bakaletz, Lauren O., Barenkamp, Stephen J., Jennings, Michael P.
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2015
Fag:
Major Articles and Brief Reports
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4539897/
https://ncbi.nlm.nih.gov/pubmed/25712964
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/infdis/jiv103
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